UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q18PI6
Entry Name

SLAF5_MOUSE
Protein Name

SLAM family member 5
Primary Gene Name

Cd84
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD84
Cell Type
Substrate Description self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. modulate the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease cell receptor
Short Summary of Papers CD84 is cleaved from the surface of human and murine platelets, reveal a dual regulation mechanism for platelet CD84 by simultaneous extra and intracellular cleavage that may modulate platelet-platelet and platelet-immune cell interactions.
Cleavage Information ZNo-Human:
PMID 23025437



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 221
Transmembrane
 		222 242



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM10 23025437   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825