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| UniProt ID |
Q16853 |
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| Entry Name |
AOC3_HUMAN |
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| Protein Name |
Membrane primary amine oxidase |
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| Primary Gene Name |
AOC3 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Oxidoreductase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Vascular adhesion protein 1(VAP-1) | |
| Cell Type | ||
| Substrate Description | cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MMP2, MMP9 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | high glucose and inflammatory cytokines facilitate shedding of membrane-bound VAP-1 from retinal capillary endothelial cells through the action of MMP-2 and MMP-9, and the soluble sVAP-1 accumulated in the vitreous fluid presumably induces oxidative stress in PDR eyes. | |
| Cleavage Information | NONE | |
| PMID | 22618595 |
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Start | End |
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6 | 26 |
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27 | 763 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | MMP2,MMP9 | 22618595 | |||||