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| UniProt ID |
Q16820 |
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| Entry Name |
MEP1B_HUMAN |
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| Protein Name |
Meprin A subunit beta |
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| Primary Gene Name |
MEP1B |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Secreted |
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| Substrate Name | meprin β | |
| Cell Type | ||
| Substrate Description | membrane metallopeptidase that sheds many membrane-bound proteins | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17, ADAM10 | |
| Shedding-related Disease | protease (metalloproteinase) | |
| Short Summary of Papers | shedding of hmeprinβ may also be a means of down-regulating the proteolytic activity | |
| Cleavage Information | NONE | |
| PMID | 25617491 12941954 |
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Start | End |
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23 | 652 |
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653 | 673 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AQIR*NSII | 61 | kallikrein-related peptidase 4 | physiologically relevant | NONE | 18627343 | ||
| MEROPS | AQIR*NSII | 61 | kallikrein-related peptidase 5 | physiologically relevant | NONE | 18627343 | ||
| MEROPS | YVLE*DSLE | 80 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | LNST*QIQL | 594 | ADAM17 | 25617491 12941954 | ||||
| PAPER | QIQL*TPAP | 598 | ADAM17 | 25617491 12941954 | ||||