UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q16819
Entry Name

MEP1A_HUMAN
Protein Name

Meprin A subunit alpha
Primary Gene Name

MEP1A
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Metalloprotease
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name meprin α
Cell Type
Substrate Description metalloendopeptidases, hydrolysis of protein and peptide substrates
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase furin
Shedding-related Disease protease (metalloproteinase)
Short Summary of Papers proteolytic cleavage during biosynthesis to generate mature form
Cleavage Information NONE
PMID 25617491 9439598



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		66 712
Transmembrane
 		713 740



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD QKSR*NGLR 65 Plasminogen 12189145   
MEROPS QKSR*NGLR 65 kallikrein-related peptidase 5 physiologically relevant NONE 18627343   
MEROPS QKSR*NGLR 65 kallikrein-related peptidase 4 physiologically relevant consensus sequence 15389820   
PMAP QKSR*NGLR 65 cationic trypsin This entry is based on an experiment 12189145   
PMAP QKSR*NGLR 65 plasmin This entry is based on an experiment 12189145   
MEROPS NCFR*SIDL 561 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS CFRS*IDLG 562 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS CFRS*IDLG 562 meprin beta subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS FRSI*DLGW 563 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS RSID*LGWS 564 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS DLGW*SGFI 567 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS DLGW*SGFI 567 meprin beta subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS RQKR*SVEN 653 furin not physiologically relevant consensus sequence 18505722   
MEROPS RQKR*SVEN 653 PCSK2 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RQKR*SVEN 653 PCSK4 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RQKR*SVEN 653 PCSK6 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RQKR*SVEN 653 PCSK5 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RQKR*SVEN 653 PCSK7 peptidase not physiologically relevant consensus sequence 18505722   
PMAP RQKR*SVEN 653 furin This entry is based on an experiment Gel electrophoresis 7626036   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17373841
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 16104056
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 24418523
HCSD cancer(colorectal cancer) 22506683