UniProt Summary
UniProt ID

Q16790

Entry Name

CAH9_HUMAN

Protein Name

Carbonic anhydrase 9

Primary Gene Name

CA9

Organism

Homo sapiens (Human)

Molecular Function

Lyase

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name carbonic anhydrase IX
Cell Type
Substrate Description hydration of carbon dioxide
Substrate Function Category disease;enzyme
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cancer (renal carcinoma);anhydrase
Short Summary of Papers cleavage of CA IX ectodomain is a regulated process that responds to physiological factors and signal transduction stimuli; soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients.
Cleavage Information NONE
PMID 9439598



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
38 414
Transmembrane
415 435



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PVHP*QRLP 37 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER REED*PPGE 76 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM17 9439598   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 22623176