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| UniProt ID |
Q16625 |
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| Entry Name |
OCLN_HUMAN |
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| Protein Name |
Occludin |
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| Primary Gene Name |
OCLN |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | occludin | |
| Cell Type | ||
| Substrate Description | formation and regulation of the tight junction (TJ) paracellular permeability barrier | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | ||
| Sheddase | MMP2, MMP7 | |
| Shedding-related Disease | tight junction (cell junction) | |
| Short Summary of Papers | cleavage of the occludin protein by MMP is involved in estrogen's decrease of tight junctional resistance and remodeling of occludin. | |
| Cleavage Information | NONE | |
| PMID | 17038551 15472219 24665393 |
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Start | End |
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67 | 89 |
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90 | 135 |
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136 | 160 |
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171 | 195 |
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196 | 243 |
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244 | 265 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | DRGY*GTSL | 93 | peptidase 1 (mite) | physiologically relevant | NONE | 10393706 | ||
| MEROPS | RGYG*TSLL | 94 | peptidase 1 (mite) | physiologically relevant | NONE | 10393706 | ||
| MEROPS | GTSL*LGGS | 97 | peptidase 1 (mite) | physiologically relevant | NONE | 10393706 | ||
| ASCENT | GYGY*GYGY | 122 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | GYGY*GYGY | 122 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | GYGY*GYGY | 122 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| ASCENT | GYGY*GYGY | 124 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | PTAQ*SSGS | 202 | allergen 13 (Penicillium sp.) | physiologically relevant | Mass spectroscopy | 16436150 | ||
| MEROPS | YGSQ*IYAL | 211 | allergen 13 (Penicillium sp.) | physiologically relevant | Mass spectroscopy | 16436150 | ||
| MEROPS | AATG*LYVD | 226 | matrix metallopeptidase-7 | physiologically relevant | consensus sequence | 17038551 | ||
| MEROPS | ERVD*SPMA | 320 | caspase-3 | physiologically relevant | NONE | 15054114 | ||
| PMAP | ERVD*SPMA | 320 | caspase-3 | This entry is based on an experiment | N-terminal sequencing | 15054114 | ||
| MEROPS | RAGR*SKRT | 389 | trypsin 1 | not physiologically relevant | NONE | 14512431 | ||
| PAPER | No_information | MMP2 | 15472219 | |||||
| PMAP | No_information | peptidase 1 (mite) | This entry is based on an experiment | Gel electrophoresis | 10393706 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| HCSD | cancer(prostate cancer) | 22908226 | |