UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q15762
Entry Name

CD226_HUMAN
Protein Name

CD226 antigen
Primary Gene Name

CD226
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD226
Cell Type
Substrate Description lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
Substrate Function Category disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cancer
Short Summary of Papers sCD226 might be shed from cell membranes and may be used as a predictor for monitoring cancer or a possible immunotherapy target
Cleavage Information NONE
PMID 19490613



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 254
Transmembrane
 		255 275



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RALC*EEVL 18 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 8673704   
PAPER No_information (unknown) 19490613   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327