UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q15465
Entry Name

SHH_HUMAN
Protein Name

Sonic hedgehog protein
Primary Gene Name

SHH
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Developmental protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Sonic hedgehog protein
Cell Type Human Bosc23 or HEK293 cells (Human Embryonic Kidney 293 cells)
Substrate Description cell fate and development
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth (morphogens)
Sheddase ADAM17
Shedding-related Disease morphogens
Short Summary of Papers ectodomain shedding of ShhNp (lipidated and membrane-tethered Sonic hedgehog), resulting in a soluble and biologically active morphogen
Cleavage Information Lipid-anchor
PMID 23118222



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS SGLA*CGPG 23 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 9593755   
PAPER GFGK*RRHP 32 ADAM17 Site-directed exchange of residue 23118222   
PAPER RHPK*KLTP 37 ADAM17 Automated Edman degradation 23118222   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA