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|---|---|---|
| UniProt ID |
Q15303 |
|
| Entry Name |
ERBB4_HUMAN |
|
| Protein Name |
Receptor tyrosine-protein kinase erbB-4 |
|
| Primary Gene Name |
ERBB4 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Tyrosine-protein kinase |
|
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | ERBB4 (HER4) | |
| Cell Type | NIH 3T3 cells | |
| Substrate Description | ERBB receptors signaling | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor receptor (ERBBs) | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | growth factor receptor (ERBBs) | |
| Short Summary of Papers | shedding result in a fragment with constitutive kinase activity, followed by RIP (regulated intramembrane proteolysis) | |
| Cleavage Information | NONE | |
| PMID | 12475204 |
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|---|---|---|
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Start | End |
|
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26 | 651 |
|
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652 | 675 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | WTGH*STLP | 641 | ADAM17 peptidase | physiologically relevant | N-terminal sequencing | 12869563 | ||
| PMAP | WTGH*STLP | 641 | ADAM17 peptidase | This entry is based on an experiment | 12869563 9685416 10744726 | |||
| MEROPS | LTFA*VYVR | 672 | presenilin 1 | physiologically relevant | NONE | 11741961 | ||
| PMAP | LTFA*VYVR | 672 | presenilin 1 | This entry is based on an experiment | 12223485 11679632 | |||
| HPRD | TFAV*YVRR | 673 | ADAM 17 | 10744726 15534001 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16047308 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |