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| UniProt ID |
Q15262 |
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| Entry Name |
PTPRK_HUMAN |
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| Protein Name |
Receptor-type tyrosine-protein phosphatase kappa |
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| Primary Gene Name |
PTPRK |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Receptor-type tyrosine-protein phosphatase kappa (PTPRK) | |
| Cell Type | ||
| Substrate Description | protein tyrosine phosphatase (PTP) family. Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | PC5 protease | |
| Shedding-related Disease | cancer (tumor invasion) | |
| Short Summary of Papers | shedding of the PTPK ectodomain is assumed to be linked to a net loss of molecules that are involved in homophilic binding and increase in cell motility(cancer cells) | |
| Cleavage Information | NONE | |
| PMID | 16404719 |
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Start | End |
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27 | 752 |
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753 | 774 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | IATK*AATE | 731 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | PC5 protease | 16404719 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |