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|---|---|---|
| UniProt ID |
Q15223 |
|
| Entry Name |
NECT1_HUMAN |
|
| Protein Name |
Nectin-1 |
|
| Primary Gene Name |
NECTIN1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Host cell receptor for virus entry |
|
| Membrane Location |
Secreted |
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| Substrate Name | nectin-1α | |
| Cell Type | ||
| Substrate Description | neurite outgrowth-promoting activity, development of ectodermal structures | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | ectodomain shedding of nectin-1 regulates dendritic spine density and related synaptic functions. shedding of nectin-1 result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes | |
| Cleavage Information | NONE | |
| PMID | 22118475 20501653 24665393 |
| Substrate Name | nectin-1α | |
| Cell Type | ||
| Substrate Description | neurite outgrowth-promoting activity, development of ectodermal structures | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | ectodomain shedding of nectin-1 regulates dendritic spine density and related synaptic functions. shedding of nectin-1 result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes | |
| Cleavage Information | NONE | |
| PMID | 22118475 20501653 24665393 |
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Start | End |
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31 | 355 |
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356 | 376 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | TYIC*EATN | 316 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM10 | 22118475 | |||||
| PMAP | No_information | presenilin 1 | This entry is based on an experiment | 12376527 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |