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| UniProt ID |
Q15109 |
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| Entry Name |
RAGE_HUMAN |
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| Protein Name |
Advanced glycosylation end product-specific receptor |
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| Primary Gene Name |
AGER |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | receptor for advanced glycation end products (RAGE) | |
| Cell Type | ||
| Substrate Description | mediates interactions of advanced glycosylation end products (AGE),chronic inflammatory diseases,complication of diabetes | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, MMP9 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | after ectodomain shedding by MMPs, the shed AGE was subsequently cleaved by γ-secretase (regulated intramembrane proteolysis) | |
| Cleavage Information | NONE | |
| PMID | 18952609 |
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Start | End |
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23 | 342 |
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343 | 363 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | V~G | 316* | ADAM10,MMP9 | 18629001 | ||||