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| UniProt ID |
Q14956 |
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| Entry Name |
GPNMB_HUMAN |
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| Protein Name |
Transmembrane glycoprotein NMB |
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| Primary Gene Name |
GPNMB |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | GPNMB/Osteoactivin (OA) | |
| Cell Type | ||
| Substrate Description | pigmentation-related gene in melanosomes, promotes the migration, invasion and metastasis of breast cancer cells | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cancer (breast cancer) | |
| Short Summary of Papers | ectodomain shedding may serve as a novel mechanism by which GPNMB/OA promotes angiogenesis in breast cancer | |
| Cleavage Information | NONE | |
| PMID | 20711474 20056711 |
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Start | End |
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23 | 498 |
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499 | 519 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | SHHN*VFPD | 154 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | SHHN*VFPD | 154 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | CPPP*PPPP | 326 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM10 | 20711474 | |||||