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| UniProt ID |
Q14627 |
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| Entry Name |
I13R2_HUMAN |
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| Protein Name |
Interleukin-13 receptor subunit alpha-2 |
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| Primary Gene Name |
IL13RA2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | IL-13R alpha2 | |
| Cell Type | ||
| Substrate Description | binds as a monomer with high affinity to interleukin-13 (IL13). | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MMP8 | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | secrete soluble IL-13Rα2 is released via proteolytic cleavage of cell surface IL-13Rα2 by metalloprotease , causing the autocrine and paracrine downregulation of the IL-13/STAT6 signal. | |
| Cleavage Information | NONE | |
| PMID | 17603012 18694590 |
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Start | End |
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27 | 343 |
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344 | 363 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | TSSS*DTEI | unknown peptidase | physiologically relevant | Mass spectroscopy | 26796116 | |||
| PAPER | No_information | metalloprotease | 17603012 18694590 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |