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| UniProt ID |
Q14574 |
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| Entry Name |
DSC3_HUMAN |
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| Protein Name |
Desmocollin-3 |
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| Primary Gene Name |
DSC3 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | desmocollin-3 | |
| Cell Type | ||
| Substrate Description | cell junctions, desmosome | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | desmosome (cell junction) | |
| Short Summary of Papers | extracellular domain shedding by metalloproteinase during disruption of the desmosome structure and apoptosis | |
| Cleavage Information | NONE | |
| PMID | 11500511 24665393 |
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Start | End |
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136 | 690 |
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691 | 711 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | VILN*VPSK | 38 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | VILN*VPSK | 38 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| ASCENT | AYAS*TADG | 216 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | AYAS*TADG | 216 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | AYAS*TADG | 216 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| ASCENT | TADG*YSAD | 220 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ADGY*SADL | 221 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | GVVC*ATDR | 266 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | TPAA*QYVR | 475 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | metalloproteinase | 11500511 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||
| HCSD | cancer(colorectal cancer) | 25216327 | |