|
|
||
|---|---|---|
| UniProt ID |
Q14242 |
|
| Entry Name |
SELPL_HUMAN |
|
| Protein Name |
P-selectin glycoprotein ligand 1 |
|
| Primary Gene Name |
SELPLG |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Host cell receptor for virus entry |
|
| Membrane Location |
Membrane |
|
|
|
|---|
| Substrate Name | P-selectin glycoprotein ligand 1 (PSGL-1, CD162) | |
| Cell Type | ||
| Substrate Description | leukocyte adhesion in inflammatory reactions | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | BACE1, ADAM8 | |
| Shedding-related Disease | ligand | |
| Short Summary of Papers | the shedding of PSGL-1 mediated by ADAM8 enhanced invasiveness of neutrophils into injured muscle fibers by the removal of their adhesiveness to blood vessels; PSGL-1 is also cleavaged by BACE1. | |
| Cleavage Information | NONE | |
| PMID | 14507929 25511460 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
18 | 320 |
|
|
321 | 341 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | EYEY*LDYD | 48 | cathepsin G | physiologically relevant | NONE | 11520793 | ||
| MEROPS | YLDY*DFLP | 51 | najalysin | not physiologically relevant | NONE | NONE | ||
| MEROPS | YLDY*DFLP | 51 | mocarhagin | not physiologically relevant | NONE | 7592904 | ||
| MEROPS | ASNL*SVNY | 303 | memapsin-2 | physiologically relevant | NONE | 14507929 | ||
| PAPER | ASNL*SVNY | 303 | BACE1 | 14507929 | ||||