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| UniProt ID |
Q14126 |
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| Entry Name |
DSG2_HUMAN |
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| Protein Name |
Desmoglein-2 |
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| Primary Gene Name |
DSG2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | Desmoglein-2 (DSG2) | |
| Cell Type | intestinal epithelial cells | |
| Substrate Description | cell junctions, desmosome | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | ADAM10, MMP9 | |
| Shedding-related Disease | desmosome (cell junction) | |
| Short Summary of Papers | the shed Dsg2 ectodomains influence intercellular adhesion and epithelial proliferation, influences intestinal epithelial homeostasis | |
| Cleavage Information | NONE | |
| PMID | 26224314 |
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Start | End |
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50 | 609 |
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610 | 634 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | VGSG*LHLQ | 23 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | RQKR*AWIT | 49 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | RQKR*AWIT | 49 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | RQKR*AWIT | 49 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | KRAW*ITAP | 51 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | YRIV*SLEP | 201 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | YRIV*SLEP | 201 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | VQIR*ILDV | 261 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | IRIL*DVND | 263 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | VLEG*MVEE | 279 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | IGSD*NWLA | 304 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| MEROPS | IGSD*NWLA | 304 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| ASCENT | TLIK*EVDY | 338 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | KSIR*SKYK | 365 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | GQII*GNFQ | 410 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | VKIV*AISE | 470 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | VKIV*AISE | 470 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | EIQF*LISD | 570 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | EIQF*LISD | 570 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | VLTL*TVCE | 588 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LTLT*VCEC | 589 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | YVTG*STMP | 943 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Gel electrophoresis | 16782893 | |||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Gel electrophoresis | 16782893 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |