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| UniProt ID |
Q14118 |
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| Entry Name |
DAG1_HUMAN |
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| Protein Name |
Dystroglycan |
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| Primary Gene Name |
DAG1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Postsynaptic cell membrane |
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| Substrate Name | Dystroglycan | |
| Cell Type | ||
| Substrate Description | provide link between the ECM and cortical cytoskeleton | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule (dystrophin complex) | |
| Sheddase | MMP2, MMP9 | |
| Shedding-related Disease | dystroglycan complex | |
| Short Summary of Papers | MMPs degrade DG complex components and disrupt the link between the ECM and cell membrane, presumed to have a deleterious effect on the stability of cell membrane | |
| Cleavage Information | NONE | |
| PMID | 19946898 16701552 |
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Start | End |
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654 | 749 |
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750 | 775 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | MAQS*HWPS | 29 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | FNSN*SQLM | 557 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | ITRG*SIVV | 653 | dystroglycan | physiologically relevant | NONE | 12798792 | ||
| ASCENT | SCRH*LQFI | 715 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | SCRH*LQFI | 715 | matrix metallopeptidase-9 | not physiologically relevant | Mass spectroscopy | 19946898 | ||
| ASCENT | CRHL*QFIP | 716 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | RHLQ*FIPV | 717 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Cerebrospinal fluid | 14998169 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16944932 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(lung cancer) | 21186846 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(colorectal cancer) | 22506683 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |