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| UniProt ID |
Q14116 |
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| Entry Name |
IL18_HUMAN |
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| Protein Name |
Interleukin-18 |
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| Primary Gene Name |
IL18 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | IL-18 | |
| Cell Type | ||
| Substrate Description | augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | caspase-1 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | LPS stimulation of macrophages induced shedding and release of membrane-bound form of IL-18 (mIL-18). sIL-18 secretion by macrophages could depend on the protease-mediated shedding of its membrane-bound form. | |
| Cleavage Information | NONE | |
| PMID | 22678914 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | LESD*YFGK | 36 | Caspase 1 | 9334240 | ||||
| MEROPS | LESD*YFGK | 36 | caspase-1 | physiologically relevant | NONE | 9334240 | ||
| MEROPS | LESD*YFGK | 36 | caspase-4 | physiologically relevant | NONE | 15326478 | ||
| PMAP | LESD*YFGK | 36 | caspase-1 | This_entry_is_based_on_an_experiment. | 9334240 | |||
| MEROPS | IRNL*NDQV | 51 | meprin beta subunit | physiologically relevant | Mass spectroscopy | 18786924 | ||
| MEROPS | QVLF*IDQG | 57 | chymase (Homo sapiens-type) | physiologically relevant | NONE | 19073880 | ||
| MEROPS | QVLF*IDQG | 57 | mast cell peptidase 5 (mouse numbering) | physiologically relevant | N-terminal sequencing | 17142727 | ||
| HPRD | DMTD*SDCR | 71 | Caspase 3, apoptosis-related cysteine peptidase | 9334240 | ||||
| MEROPS | DMTD*SDCR | 71 | caspase-3 | physiologically relevant | NONE | 9334240 | ||
| PMAP | DMTD*SDCR | 71 | caspase-3 | This_entry_is_based_on_an_experiment. | 9334240 | |||
| HPRD | DCRD*NAPR | 76 | Caspase 3, apoptosis-related cysteine peptidase | 9334240 | ||||
| MEROPS | DCRD*NAPR | 76 | caspase-3 | physiologically relevant | NONE | 9334240 | ||
| PMAP | DCRD*NAPR | 76 | caspase-3 | This_entry_is_based_on_an_experiment. | 9334240 | |||
| MEROPS | KMQF*ESSS | 151 | chymase (Homo sapiens-type) | physiologically relevant | NONE | 19073880 | ||
| MEROPS | KMQF*ESSS | 151 | mast cell peptidase 5 (mouse numbering) | physiologically relevant | N-terminal sequencing | 17142727 | ||
| PAPER | No_information | caspase-1 | 22678914 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |