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| UniProt ID |
Q14114 |
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| Entry Name |
LRP8_HUMAN |
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| Protein Name |
Low-density lipoprotein receptor-related protein 8 |
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| Primary Gene Name |
LRP8 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
|
| Membrane Location |
Secreted |
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| Substrate Name | ApoER2 | |
| Cell Type | ||
| Substrate Description | cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. | |
| Substrate Function Category | lipid (lipoprotein receptor famiy) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | NGF induces ApoER2 shedding by metalloprotease, and the proteolytic processing is regulated by ApoER2 ligand Reelin; ApoER2 undergoes RIP(regulated intramembrane proteolysis) after the shedding of extracellular domain. | |
| Cleavage Information | NONE | |
| PMID | 25233900 15950758 |
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Start | End |
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42 | 826 |
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827 | 847 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | HLAA*AAAD | 31 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | HLAA*AAAD | 31 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LAAA*AADP | 32 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | ADAM | 25233900 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |