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|---|---|---|
| UniProt ID |
Q13444 |
|
| Entry Name |
ADA15_HUMAN |
|
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 15 |
|
| Primary Gene Name |
ADAM15 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Membrane |
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|---|
| Substrate Name | ADAM15 | |
| Cell Type | ||
| Substrate Description | diverse cellular process regulated by proteolytic cleavage | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | protease (metalloproteinase) | |
| Short Summary of Papers | shedding of the ADAM15 ectodomain was induced by cancer cell-released factors, and was associated with serine protease activity, not metalloprotease activity.The ADAM15 ectodomain suppressed cancer cell migration and activation of the MEK/ERK signaling pathway. | |
| Cleavage Information | NONE | |
| PMID | 25208722 |
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|---|---|---|
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Start | End |
|
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207 | 696 |
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697 | 717 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | QVLQ*DDLP | 50 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | RRRR*DVVT | 206 | furin | physiologically relevant | consensus sequence | 9748307 | ||
| ASCENT | GHSL*GLDH | 354 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | (unknown) | 25208722 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |