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| UniProt ID |
Q13421 |
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| Entry Name |
MSLN_HUMAN |
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| Protein Name |
Mesothelin |
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| Primary Gene Name |
MSLN |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | mesothelin (MPF) | |
| Cell Type | ||
| Substrate Description | play a role in cellular adhesion. potentiates megakaryocyte colony formation. | |
| Substrate Function Category | Immune and Inflammation;disease | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cell adhesion molecule; cancer (ovarian carcinoma, mesothelioma ) | |
| Short Summary of Papers | megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tmor marker in the serum of patients with mesothelioma; soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. | |
| Cleavage Information | GPI-anchor | |
| PMID | 10500211 16857795 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PSRT*LAGE | 36 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 7665620 | ||
| MEROPS | RFRR*EVEK | 295 | unknown peptidase | physiologically relevant | NONE | 8552591 | ||
| PAPER | No_information | (unknown) | 10500211 16857795 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Tear | 16335950 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck cancer) | 21598386 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(metastatic non-small-cell lung cancer) | 24667143 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |