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| UniProt ID |
Q13308 |
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| Entry Name |
PTK7_HUMAN |
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| Protein Name |
Inactive tyrosine-protein kinase 7 |
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| Primary Gene Name |
PTK7 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | Protein-tyrosine Pseudokinase 7 (PTK7) | |
| Cell Type | ||
| Substrate Description | inactive tyrosine kinase involved in Wnt signaling pathway,modulates cell polarity and motility in diverse biological processes such as embryo development and cancer cell invasion | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | MT1MMP | |
| Shedding-related Disease | cancer (tumor invasion) | |
| Short Summary of Papers | ectodomain shedding is required for RIP (regulated intramembrane proteolysis)of PTK7 by γ-secretase, and the proteolytic regulation of PTK7 might be involved in cancer cell invasion | |
| Cleavage Information | NONE | |
| PMID | 23095747 |
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Start | End |
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31 | 704 |
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705 | 725 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GTQT*AIVF | 30 | signal peptidase complex (animal) | physiologically relevant | Mass spectroscopy | 16179924 | ||
| PAPER | FAQG*SSLS | 82 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SLSF*AAVD | 87 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TFQC*VARD | 101 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | FNIK*WIEA | 122 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | KHPA*SEAE | 135 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | HPAS*EAEI | 136 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PASE*AEIQ | 137 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ASEA*EIQP | 138 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ILEA*TLHL | 315 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | FEPR*VFTA | 331 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | LRIN*SVEV | 469 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | WYRC*MSST | 481 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TPAG*SIEA | 488 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SIEA*QARV | 492 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | IEAQ*ARVQ | 493 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PQPQ*QCME | 511 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | QPQQ*CMEF | 512 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | QQCM*EFDK | 514 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VTDN*AGTL | 551 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DNAG*TLHF | 553 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GHTA*LLQC | 609 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DPKP*LIQW | 621 | MT1-MMP | 23095747 | ||||
| PAPER | GNSC*NIKH | 670 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | NSCN*IKHT | 671 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VPEE*SEGP | 689 | UNKNOWN | Mass spectrometry | 33796845 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |