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|---|---|---|
| UniProt ID |
Q08345 |
|
| Entry Name |
DDR1_HUMAN |
|
| Protein Name |
Epithelial discoidin domain-containing receptor 1 |
|
| Primary Gene Name |
DDR1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Kinase |
|
| Membrane Location |
Secreted |
|
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|---|
| Substrate Name | discoidin domain receptor 1 (DDR1) | |
| Cell Type | ||
| Substrate Description | tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | collagen receptor | |
| Short Summary of Papers | collagen type I stimulates shedding of the DDR1 ectodomain mediated in part by Src-dependent activation or recruitment of a metalloproteinase, the shedding may regulate cellular responses to collagen | |
| Cleavage Information | NONE | |
| PMID | 16440311 |
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|---|
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|---|---|---|
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Start | End |
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21 | 417 |
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418 | 438 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | QTMY*LSEA | 203 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 16440311 | |||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 16440311 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(lung cancer) | 21806062 | |