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| UniProt ID |
Q07954 |
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| Entry Name |
LRP1_HUMAN |
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| Protein Name |
Prolow-density lipoprotein receptor-related protein 1 |
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| Primary Gene Name |
LRP1 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | low-density lipoprotein receptor-related protein 1 (LRP1) | |
| Cell Type | ||
| Substrate Description | cellular lipid homeostasis, clearance of secreted amyloid precursor protein and beta-amyloid | |
| Substrate Function Category | lipid (metabolism) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | Increased LRP1 shedding during aging could contribute to the pathogenesis of AD. | |
| Cleavage Information | NONE | |
| PMID | 19371428 |
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Start | End |
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20 | 4419 |
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4420 | 4444 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | MHMK*VYDE | 1834 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | PNDK*SDAL | 1911 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | SRAK*RDQT | 1950 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | RGGR*ILQD | 2509 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | RHRR*QIDR | 3943 | Furin | 2112085 8546712 | ||||
| MEROPS | RHRR*QIDR | 3943 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RHRR*QIDR | 3943 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RHRR*QIDR | 3943 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RHRR*QIDR | 3943 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RHRR*QIDR | 3943 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RHRR*QIDR | 3943 | furin | physiologically relevant | NONE | 8546712 | ||
| PAPER | No_information | ADAM10,ADAM17 | 19371428 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |