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| UniProt ID |
Q07021 |
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| Entry Name |
C1QBP_HUMAN |
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| Protein Name |
Complement component 1 Q subcomponent-binding protein, mitochondrial |
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| Primary Gene Name |
C1QBP |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | receptor of complement component 1q(gC1qR) | |
| Cell Type | ||
| Substrate Description | gC1qR represents a receptor of complement component 1q. multifunctional and multicompartmental protein involved in inflammation and infection processess. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MT1-MMP | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | gC1qR is susceptible to MT1-MMP proteolysis. MT1-MMP forms an enzyme-substrate complex with released gC1qR and cleaves this protein. | |
| Cleavage Information | GPI-anchor | |
| PMID | 11773076 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | GCGS*LHTD | 73 | 8195709 | |||||
| MEROPS | DKAF*VDFL | 82 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | AFVD*FLSD | 84 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | FVDF*LSDE | 85 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | KEER*KIQK | 94 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | NINN*SIPP | 137 | cathepsin S | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| HPRD | PSQG*QKVE | 152 | Matrix metalloproteinase 14 | 11773076 | ||||
| MEROPS | PSQG*QKVE | 152 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 11773076 | ||
| PMAP | PSQG*QKVE | 152 | membrane-type matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 11773076 | ||
| MEROPS | QGQK*VEEQ | 154 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VEEQ*EPEL | 158 | LAST_MAM peptidase (Limulus-type) | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | EPEL*TSTP | 162 | LAST_MAM peptidase (Limulus-type) | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | PELT*STPN | 163 | elastase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | PELT*STPN | 163 | cathepsin G | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ELTS*TPNF | 164 | astacin | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | ELTS*TPNF | 164 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | STPN*FVVE | 167 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | EVIK*NDDG | 174 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 17081049 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(metastatic non-small-cell lung cancer) | 24667143 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |