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| UniProt ID |
Q06481 |
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| Entry Name |
APLP2_HUMAN |
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| Protein Name |
Amyloid-like protein 2 |
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| Primary Gene Name |
APLP2 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
DNA-binding |
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| Membrane Location |
Cell membrane |
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| Substrate Name | amyloid precursor protein-like protein 2(APLP2) | |
| Cell Type | ||
| Substrate Description | may play a role in the regulation of hemostasis; neurite outgrowth | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | Integral membrane protein | |
| Short Summary of Papers | Retinoic acid (RA) treatment lead to an increased release of soluble APLP2, the APLP2 are subjected to RIP (regulated intramembrane proteolysis) by γ-secretase after ectodomain shedding | |
| Cleavage Information | NONE | |
| PMID | 16279945 12228233 |
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Start | End |
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32 | 692 |
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693 | 716 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | LAGY*IEAL | 33 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | IEAL*AANA | 37 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ALAA*NAGT | 39 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | EFVS*DVLL | 140 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | MTLY*SYGM | 182 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DYCM*AVCK | 357 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VETH*LARV | 456 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | NYLA*ALQS | 477 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | LDVK*EMIF | 662 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LDVK*EMIF | 662 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | ADAM10 | 16279945 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Cerebrospinal fluid | 14998169 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck cancer) | 21598386 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |