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|---|---|---|
| UniProt ID |
Q05928 |
|
| Entry Name |
BTC_MOUSE |
|
| Protein Name |
Probetacellulin [Cleaved into: Betacellulin |
|
| Primary Gene Name |
Btc |
|
| Organism |
Mus musculus (Mouse) |
|
| Molecular Function |
Mitogen |
|
| Membrane Location |
Secreted |
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|---|
| Substrate Name | betacellulin (BTC) | |
| Cell Type | ||
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM17, ADAM10 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | produce soluble mature growth factor (as soluble agonist of EGFR) | |
| Cleavage Information | NONE | |
| PMID | 14993236 11823465 18951988 |
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|---|---|---|
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Start | End |
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32 | 118 |
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119 | 139 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | CVVA*DGNT | 31 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 8456283 | ||
| MEROPS | DLFY*LQQD | 111 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| PMAP | DLFY*LQQD | 111 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15066986 | ||
| PMAP | No_information | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | 14993236 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |