UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q05683
Entry Name

DCE2_RAT
Protein Name

Glutamate decarboxylase 2
Primary Gene Name

Gad2
Organism

Rattus norvegicus (Rat)
Molecular Function

Decarboxylase
Lyase
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name glutamic acid decarboxylase 65 (GAD65)
Cell Type
Substrate Description catalyzes the production of GABA.
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase calpain
Shedding-related Disease decarboxylase
Short Summary of Papers GAD65 could be cleaved to release a stable truncated form. upon sustained neuronal stimulation, GAD65 could be cleaved into a truncated form in a rat synaptosomal preparation, and the proteolytic cleavage may be mediated by calpain.
Cleavage Information ZNo-Human:
PMID 16879709



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information calpain 16879709   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA