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| UniProt ID |
Q04721 |
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| Entry Name |
NOTC2_HUMAN |
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| Protein Name |
Neurogenic locus notch homolog protein 2 |
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| Primary Gene Name |
NOTCH2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Activator |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Notch2 | |
| Cell Type | ||
| Substrate Description | cell fate and development | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | Central nervous system (CNS) pathology; receptor | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | ectodomain shedding result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes | |
| Cleavage Information | NONE | |
| PMID | 10958687 24842903 |
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Start | End |
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26 | 1677 |
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1678 | 1698 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | MTRR*SLPG | 1608 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | MTRR*SLPG | 1608 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | MTRR*SLPG | 1608 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| PAPER | MTRR*SLPG | 1608 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | PLVS*VVSE | 1665 | 11518718 | |||||
| HPRD | ILLG*VIMA | 1696 | 11518718 | |||||
| PAPER | No_information | ADAM10 | 24842903 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |