UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q03431
Entry Name

PTH1R_HUMAN
Protein Name

Parathyroid hormone/parathyroid hormone-related peptide receptor
Primary Gene Name

PTH1R
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name parathyroid hormone (PTHR)
Cell Type
Substrate Description G-protein coupled receptor .receptor for parathyroid hormone and for parathyroid hormone-related peptide
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers PTHR extracellular domain is cleaved by a metalloproteinase, and the shedding may be involved in the stability regulation of PTHR
Cleavage Information NONE
PMID 20080964



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		27 188
Transmembrane
 		189 212
Transmembrane
 		220 239
Extracellular
 		240 282
Transmembrane
 		283 306
Transmembrane
 		321 342
Extracellular
 		343 361
Transmembrane
 		362 382
Transmembrane
 		410 428
Extracellular
 		429 440
Transmembrane
 		441 463



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase 20080964   
PMAP No_information calpain-2 This entry is based on an experiment Gel electrophoresis 15691895   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA