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| UniProt ID |
Q03405 |
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| Entry Name |
UPAR_HUMAN |
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| Protein Name |
Urokinase plasminogen activator surface receptor |
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| Primary Gene Name |
PLAUR |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | urokinase-type plasminogen activator receptor(uPAR,CD87) | |
| Cell Type | ||
| Substrate Description | angiogenesis; cell migration | |
| Substrate Function Category | angiogenesis | |
| Substrate Function Subtype | angiogenesis; receptor ((GPI)-anchored) | |
| Sheddase | MMP12 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | antiangiogenic capacity of MMP12 to reduce the number of functional u-PARs by shedding and release the D1 domain of u-PAR | |
| Cleavage Information | GPI-anchor | |
| PMID | 11342439 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ASWG*LRCM | 22 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 1689240 | ||
| MEROPS | NSGR*AVT | 105 | trypsin 1 | not physiologically relevant | NONE | 12195704 | ||
| MEROPS | NSGR*AVT | 105 | human airway trypsin-like peptidase | physiologically relevant | N-terminal sequencing | 17237151 | ||
| MEROPS | NSGR*AVT | 105 | urokinase-type plasminogen activator | physiologically relevant | NONE | 12195704 | ||
| MEROPS | NSGR*AVT | 105 | plasmin | physiologically relevant | NONE | 12195704 | ||
| PMAP | NSGR*AVTY | 105 | plasmin | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| PMAP | NSGR*AVTY | 105 | u-plasminogen activator | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| MEROPS | SGRA*VTY | 106 | pseudolysin | not physiologically relevant | NONE | 17517866 | ||
| MEROPS | GRAV*TYS | 107 | elastase-2 | physiologically relevant | NONE | 12195704 | ||
| PMAP | GRAV*TYSR | 107 | neutrophil elastase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 14688365 12195704 | ||
| HPRD | RAVT*YSRS | 108 | Matrix metalloproteinase 12 | 12195704 | ||||
| HPRD | RAVT*YSRS | 108 | Matrix metalloproteinase 12 | 12195704 | ||||
| HPRD | RAVT*YSRS | 108 | Matrix metalloproteinase 12 | 12195704 | ||||
| MEROPS | RAVT*YSR | 108 | pseudolysin | not physiologically relevant | NONE | 17517866 | ||
| MEROPS | RAVT*YSR | 108 | matrix metallopeptidase-3 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | RAVT*YSR | 108 | matrix metallopeptidase-12 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | RAVT*YSR | 108 | matrix metallopeptidase-19 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | RAVT*YSR | 108 | membrane-type matrix metallopeptidase-6 | physiologically relevant | NONE | 12195704 | ||
| PAPER | T*Y | 108 | MMP12 | 12195704 | ||||
| PMAP | RAVT*YSRS | 108 | matrix metallopeptidase-12 | This_entry_is_based_on_an_experiment. | 12195704 17133606 16917801 | |||
| PMAP | RAVT*YSRS | 108 | matrix metallopeptidase-19 | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| PMAP | RAVT*YSRS | 108 | membrane-type matrix metallopeptidase-6 | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| PMAP | RAVT*YSRS | 108 | matrix metallopeptidase-3 | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| MEROPS | AVTY*SRSR | 109 | chymotrypsin A (cattle-type) | not physiologically relevant | NONE | 12195704 | ||
| MEROPS | AVTY*SRSR | 109 | matrix metallopeptidase-19 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | AVTY*SRSR | 109 | membrane-type matrix metallopeptidase-6 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | AVTY*SRSR | 109 | cathepsin G | physiologically relevant | NONE | 14688365 | ||
| MEROPS | AVTY*SRSR | 109 | kallikrein-related peptidase 4 | physiologically relevant | NONE | 16497155 | ||
| PMAP | AVTY*SRSR | 109 | cathepsin G | This_entry_is_based_on_an_experiment. | Mass spectrometry | 14688365 | ||
| PMAP | AVTY*SRSR | 109 | chymotrypsin | This_entry_is_based_on_an_experiment. | Mass spectrometry | 14688365 | ||
| PMAP | AVTY*SRSR | 109 | prostase | This_entry_is_based_on_an_experiment. | 16497155 | |||
| MEROPS | VTYS*RSRY | 110 | matrix metallopeptidase-19 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | trypsin 1 | not physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | matrix metallopeptidase-19 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | membrane-type matrix metallopeptidase-6 | physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | human airway trypsin-like peptidase | physiologically relevant | N-terminal sequencing | 17237151 | ||
| MEROPS | TYSR*SRYL | 111 | urokinase-type plasminogen activator | physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | plasmin | physiologically relevant | NONE | 12195704 | ||
| MEROPS | TYSR*SRYL | 111 | kallikrein-related peptidase 4 | physiologically relevant | NONE | 16497155 | ||
| PMAP | TYSR*SRYL | 111 | plasmin | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15358545 | ||
| PMAP | TYSR*SRYL | 111 | u-plasminogen activator | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15358545 | ||
| PMAP | TYSR*SRYL | 111 | prostase | This_entry_is_based_on_an_experiment. | 16497155 | |||
| PMAP | TYSR*SRYL | 111 | plasmin | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| PMAP | TYSR*SRYL | 111 | u-plasminogen activator | This_entry_is_based_on_an_experiment. | Mass spectrometry | 12195704 | ||
| MEROPS | RSRY*LECI | 114 | cathepsin G | physiologically relevant | NONE | 14688365 | ||
| MEROPS | LDVQ*YRSG | 301 | pseudolysin | not physiologically relevant | NONE | 17517866 | ||
| MEROPS | VQYR*SGAA | 303 | kallikrein-related peptidase 4 | physiologically relevant | NONE | 16497155 | ||
| PMAP | VQYR*SGAA | 303 | prostase | This_entry_is_based_on_an_experiment. | 16497155 | |||
| PAPER | No_information | MMP12 | 19946898 | |||||
| PMAP | No_information | streptopain | This_entry_is_based_on_an_experiment. | Gel electrophoresis | 7982988 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |