UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q03167
Entry Name

TGBR3_HUMAN
Protein Name

Transforming growth factor beta receptor type 3
Primary Gene Name

TGFBR3
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name type III transforming growth factor β receptor(TβRIII,betaglycanm)
Cell Type tumor cells
Substrate Description cancer cell invasion, TGF-β mediated signaling regulation
Substrate Function Category disease
Substrate Function Subtype Disease: Cancers (tumor suppressor)
Sheddase metalloproteinase
Shedding-related Disease cancer (tumor suppress)
Short Summary of Papers releasing soluble TβRIII, sequesters ligand, inhibit downstream signaling in cancer migration and invasion
Cleavage Information NONE
PMID 24966170



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 787
Transmembrane
 		788 809



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT ISRR*VWNE 411 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER WAMM*QNKK 742 MMP3, MMP9 NONE mutation 24966170   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Milk 16502470
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Bronchoalveolar lavage fluid 16497942
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 15822942
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(ovarian cancer) 22623176
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD cancer(non small cell lung cancer) 19655816
locate 17986452