UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q02763
Entry Name

TIE2_HUMAN
Protein Name

Angiopoietin-1 receptor
Primary Gene Name

TEK
Organism

Homo sapiens (Human)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Tie2
Cell Type
Substrate Description regulation of angiogenesis
Substrate Function Category angiogenesis
Substrate Function Subtype angiogenesis; receptor (Tyrosine-protein kinase receptor)
Sheddase MMP
Shedding-related Disease cell receptor
Short Summary of Papers VEGF regulates angiopoietin-Tie2 signaling by inducing proteolytic cleavage and shedding of Tie2 via a novel PI3K/Akt-dependent pathway
Cleavage Information NONE
PMID 17901375



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		23 748
Transmembrane
 		749 769



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS TVEG*AMDL 22 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information ADAM12 23458101   
PAPER No_information MMP 17901375   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16104056