|
|
||
|---|---|---|
| UniProt ID |
Q02413 |
|
| Entry Name |
DSG1_HUMAN |
|
| Protein Name |
Desmoglein-1 |
|
| Primary Gene Name |
DSG1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Cell membrane |
|
|
|
|---|
| Substrate Name | Desmoglein-1 (DSG1) | |
| Cell Type | ||
| Substrate Description | cell junctions, desmosome | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | caspase, metalloproteinase | |
| Shedding-related Disease | desmosome (cell junction) | |
| Short Summary of Papers | UV-induced cleavage of the human desmoglein 1 | |
| Cleavage Information | NONE | |
| PMID | 26224314 24665393 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
50 | 548 |
|
|
549 | 569 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RQKR*EWIK | 49 | kallikrein-related peptidase 4 | physiologically relevant | consensus sequence | 15389820 | ||
| MEROPS | RQKR*EWIK | 49 | furin | physiologically relevant | NONE | 12586364 | ||
| MEROPS | LRVR*VLDI | 146 | kallikrein-related peptidase 5 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | IAFK*IIRQ | 197 | kallikrein 1 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | GSDR*DGGA | 242 | kallikrein-related peptidase 5 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | YKLK*ASAI | 368 | kallikrein-related peptidase 6 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | TTVR*YVMG | 422 | kallikrein-related peptidase 6 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | TTVR*YVMG | 422 | kallikrein-related peptidase 5 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | LTLK*NKVT | 445 | kallikrein 1 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | SQVY*SSEP | 528 | kallikrein-related peptidase 14 | physiologically relevant | N-terminal sequencing | NONE | ||
| MEROPS | DLRD*GSNV | 888 | caspase-3 | physiologically relevant | NONE | 16286477 | ||
| PMAP | DLRD*GSNV | 888 | caspase-3 | This entry is based on an experiment | Mutagenesis | 16286477 | ||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 15305340 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16740002 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 16047308 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16083276 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(lung cancer) | 21806062 | |