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| UniProt ID |
Q02297 |
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| Entry Name |
NRG1_HUMAN |
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| Protein Name |
Pro-neuregulin-1, membrane-bound isoform |
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| Primary Gene Name |
NRG1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Growth factor |
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| Membrane Location |
Secreted |
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| Substrate Name | neuregulins (NRG) | |
| Cell Type | vascular endothelial cells (ECs) | |
| Substrate Description | ERBB receptors signaling | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (ERBBs) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth factor (ERBBs) | |
| Short Summary of Papers | release of extracellular epidermal growth factor-like-containing domain as soluble agonist of ErbB3 and ErbB4 | |
| Cleavage Information | NONE | |
| PMID | 18951988 20215529 |
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Start | End |
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20 | 242 |
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243 | 265 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | NVPM*KVQN | 227 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 20215529 | |||||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 16843264 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 17081049 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| locate | 17986452 | ||