UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q01887
Entry Name

RYK_MOUSE
Protein Name

Tyrosine-protein kinase RYK
Primary Gene Name

Ryk
Organism

Mus musculus (Mouse)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Wnt receptor (Ryk)
Cell Type
Substrate Description coreceptor along with FZD8 of Wnt proteins. involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor
Short Summary of Papers Ryk undergoes a two-step cleavage that is mediated by an unknown protease and following RIP (regulated intramembrane proteolysis) to production of Ryk intracellular domain (ICD). Ryk cleavage and subsequent nuclear localization are required to mediate Wnt3-induced neuronal differentiation.
Cleavage Information ZNo-Human:
PMID 19000841



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		35 211
Transmembrane
 		212 239



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 19000841   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA