UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q01151
Entry Name

CD83_HUMAN
Protein Name

CD83 antigen
Primary Gene Name

CD83
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name CD83
Cell Type
Substrate Description antigen presentation, cellular interactions that follow lymphocyte activation
Substrate Function Category disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cancer (tumor escape)
Short Summary of Papers shedding of tumor-derived CD83 could impair T cells activation as a novel tumor evasion mechanism
Cleavage Information NONE
PMID 18513799



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 144
Transmembrane
 		145 166



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LAPA*TPEV 19 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information (unknown) 18513799   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836