UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q00657
Entry Name

CSPG4_RAT
Protein Name

Chondroitin sulfate proteoglycan 4
Primary Gene Name

Cspg4
Organism

Rattus norvegicus (Rat)
Molecular Function

Developmental protein
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Chondroitin sulfate proteoglycan 4 (NG2)
Cell Type
Substrate Description proteoglycan invovled in cell proliferation and migration, neurite outgrowth inhibition
Substrate Function Category cell surface structure
Substrate Function Subtype cell adhesion molecule
Sheddase metalloproteinase
Shedding-related Disease proteoglycan
Short Summary of Papers shedding of NG2 represents a mechanism for decreasing responsiveness to PDGF, involved in the control of cell proliferation
Cleavage Information NONE
PMID 15866049



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 2225
Transmembrane
 		2226 2250



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS STAP*ASFF 29 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 1906475   
PAPER No_information metalloproteinase 15866049   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825