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| UniProt ID |
P98172 |
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| Entry Name |
EFNB1_HUMAN |
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| Protein Name |
Ephrin-B1 |
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| Primary Gene Name |
EFNB1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Ephrin-B1 | |
| Cell Type | ||
| Substrate Description | ligand for receptor tyrosine kinases Eph receptors, migration, repulsion and adhesion during neuronal, vascular and epithelial development. | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | MMP8 | |
| Shedding-related Disease | ligand | |
| Short Summary of Papers | the cleavage of ephrin-B1 extracellular domain by MMP8 may be a negative regulation of the EphB-ephrin-B1 complex | |
| Cleavage Information | NONE | |
| PMID | 17567680 |
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Start | End |
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28 | 237 |
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238 | 258 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LATP*LAKN | 27 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| ASCENT | PGSR*GSLG | 199 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | QEEK*SGPG | 217 | matrix metallopeptidase-8 | physiologically relevant | Mass spectroscopy | 17567680 | ||
| PAPER | GPGA*SGGS | 222 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GASG*GSSG | 224 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ASGG*SSGD | 225 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PMAP | No_information | presenilin 1 | This entry is based on an experiment | Gel electrophoresis | 16930449 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |