UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P98161
Entry Name

PKD1_HUMAN
Protein Name

Polycystin-1
Primary Gene Name

PKD1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name polycystin-1 (PC1)
Cell Type
Substrate Description renal tubulogenesis, fluid-flow mechanosensation by the primary cilium in renal epithelium, regulator of cilium length
Substrate Function Category renal
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor
Short Summary of Papers the cleavage of PC1 may be required to activate signaling pathways involved in renal tubular differentiation and maturation
Cleavage Information NONE
PMID 17525154



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 3074
Transmembrane
 		3075 3095
Transmembrane
 		3278 3298
Extracellular
 		3299 3323
Transmembrane
 		3324 3344
Transmembrane
 		3560 3580
Extracellular
 		3581 3582
Transmembrane
 		3583 3603
Transmembrane
 		3666 3686
Extracellular
 		3687 3901
Transmembrane
 		3902 3922
Transmembrane
 		3936 3956
Extracellular
 		3957 3984
Transmembrane
 		3985 4005
Transmembrane
 		4028 4048
Extracellular
 		4049 4090
Transmembrane
 		4091 4110



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS TRHL*TAFG 3048 unknown peptidase physiologically relevant NONE 17525154   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Bronchoalveolar lavage fluid 16497942
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16083276
Sys-BodyFluid Plasma/Serum 15822942
Sys-BodyFluid Plasma/Serum 16104056
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(head and neck squamous cell carcinoma) 22918226