UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P98158
Entry Name

LRP2_RAT
Protein Name

Low-density lipoprotein receptor-related protein 2
Primary Gene Name

Lrp2
Organism

Rattus norvegicus (Rat)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name megalin
Cell Type opossum kidney proximal tubule (OKP) cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase matrix metalloprotease, gamma-secretase
Shedding-related Disease
Short Summary of Papers megalin undergoes ectodomain shedding and the following RIP (regulated intramembrane proteolysis) regulated by protein kinase C. the enzymatic processing of megalin represents part of a novel ligand-dependent signaling pathway in the proximal tubule that links receptor-mediated endocytosis with cell signaling
Cleavage Information
PMID 15180987



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 4425
Transmembrane
 		4426 4446



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PVSS*QECG 25 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825