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| UniProt ID |
P98155 |
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| Entry Name |
VLDLR_HUMAN |
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| Protein Name |
Very low-density lipoprotein receptor |
|
| Primary Gene Name |
VLDLR |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | VLDLr | |
| Cell Type | ||
| Substrate Description | binds VLDL and transports it into cells by endocytosis. important in neuronal migration during development | |
| Substrate Function Category | lipid (lipoprotein receptor famiy) | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | VLDLr undergo extracellular cleavages to release secreted forms of the receptors and intramembranous cleavages to degrade the C-terminal fragments. | |
| Cleavage Information | NONE | |
| PMID | 15950758 |
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|---|---|---|
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Start | End |
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28 | 797 |
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798 | 819 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | RKAK*CEPS | 32 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | QCTN*GRCI | 42 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DCSD*GSDE | 181 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | CSDG*SDEL | 182 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | FKCR*SGEC | 327 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | YECD*CAAG | 381 | caspase-1 | not physiologically relevant | Mass spectroscopy | 20173201 | ||
| PAPER | QNPG*ICSQ | 404 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | ICIN*LKGG | 412 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SKLH*MLSS | 622 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VEEN*GRDC | 745 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | metalloproteinase | 15950758 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 15048996 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |