UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P97952
Entry Name

SCN1B_MOUSE
Protein Name

Sodium channel subunit beta-1
Primary Gene Name

Scn1b
Organism

Mus musculus (Mouse)
Molecular Function

Ion channel
Sodium channel
Voltage-gated channel
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Sodium channel subunit beta 1 (Scn1b)
Cell Type
Substrate Description assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel;required to reconstitute full properties of the native sodium channel
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase BACE1 (memapsin-2)
Shedding-related Disease ion channel
Short Summary of Papers β subunits of voltage-gated sodium channels are processed by BACE1 and γ-secretase (regulated intramembrane proteolysis) sequentially; shed ectodomain may be required for β subunit-mediated neurite outgrowth
Cleavage Information ZNo-Human:
PMID 15824102 18694383



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 160
Transmembrane
 		161 182



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS KIHL*EVVD 144 memapsin-2 physiologically relevant NONE 15824102   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825