UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P97798
Entry Name

NEO1_MOUSE
Protein Name

Neogenin
Primary Gene Name

Neo1
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Neogenin
Cell Type HEK293 cells (Human Embryonic Kidney 293 cells)
Substrate Description neurite growth (inhibition)
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; neuronal receptors
Sheddase ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers proteolytic processing of axon guidance receptors for proper axon guidance
Cleavage Information Zno_human:Q92859
PMID 26651291 21645559



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		37 1136
Transmembrane
 		1137 1157



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 21645559    26651291   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825