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|---|---|---|
| UniProt ID |
P97797 |
|
| Entry Name |
SHPS1_MOUSE |
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| Protein Name |
Tyrosine-protein phosphatase non-receptor type substrate 1 |
|
| Primary Gene Name |
Sirpa |
|
| Organism |
Mus musculus (Mouse) |
|
| Molecular Function | ||
| Membrane Location |
Membrane |
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|---|
| Substrate Name | SIRPĪ± (SHPS-1) | |
| Cell Type | ||
| Substrate Description | receptor for CD47. supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. synaptogenesis and synaptic function | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | ectodomain shedding of SIRPĪ± is an activity-dependent mechanism allowing pre- and postsynaptic terminals to communicate for the maturation of functional synapse. | |
| Cleavage Information | ZNo-Human: | |
| PMID | 24036914 |
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|---|---|---|
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Start | End |
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32 | 373 |
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374 | 394 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GVTG*KELK | 31 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 9348339 | ||
| PAPER | No_information | metalloproteinase | 24036914 | |||||
| PaperC | No_information | BACE1/2 | Type I TMP | proteomics | 23430253 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||