UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P97792
Entry Name

CXAR_MOUSE
Protein Name

Coxsackievirus and adenovirus receptor homolog
Primary Gene Name

Cxadr
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Coxsackievirus and Adenovirus Receptor (CAR)
Cell Type
Substrate Description component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. involved in transepithelial migration of leukocytes
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers CAR undergoes ectodomain shedding and RIP(regulated intramembrane proteolysis) by the presenilin/γ-secretase
Cleavage Information ZNo-Human:
PMID 24015300



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 237
Transmembrane
 		238 258



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER M--L(region) 224* ADAM10 mutation 24015300   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825