UniProt Summary
UniProt ID

P97685

Entry Name

NFASC_RAT

Protein Name

Neurofascin

Primary Gene Name

Nfasc

Organism

Rattus norvegicus (Rat)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name neurofascin (NF155)
Cell Type
Substrate Description cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell adhesion molecule
Short Summary of Papers ectodomain shedding of NF155 may play a role for the generation and/or stabilization of the nodal/paranodal architecture.
Cleavage Information ZNo-Human:
PMID 16360652



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
25 1110
Transmembrane
1111 1131



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloprotease 16360652   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825