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| UniProt ID |
P80370 |
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| Entry Name |
DLK1_HUMAN |
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| Protein Name |
Protein delta homolog 1 |
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| Primary Gene Name |
DLK1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Membrane |
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| Substrate Name | Preadipocyte factor 1 (Pref-1,DLK1) | |
| Cell Type | preadipocytes | |
| Substrate Description | involved in the differentiation of several cell types including adipocytes. | |
| Substrate Function Category | lipid (adipogenesis) | |
| Substrate Function Subtype | adipocyte differentiation regulation | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | adipocyte factor | |
| Short Summary of Papers | release the 50-kDa release soluble form,inhibits adipocyte differentiation; tissue inhibitor of metalloproteinases 3 (TIMP3) modulates adipose tissue remodelling by regulating extracellular matrix turnover and shedding of the adipogenic regulator DLK1. | |
| Cleavage Information | ZNo-human:Q9NS53 | |
| PMID | 16809777 26312857 |
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Start | End |
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24 | 303 |
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304 | 327 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | STYG*AECF | 23 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| PAPER | QAIC*FTIL | 306 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AICF*TILG | 307 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TILG*VLTS | 311 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 26312857 | |||||