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| UniProt ID |
P78504 |
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| Entry Name |
JAG1_HUMAN |
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| Protein Name |
Protein jagged-1 |
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| Primary Gene Name |
JAG1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Membrane |
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| Substrate Name | Notch ligand Jagged1 | |
| Cell Type | HEK 293 cells (Human Embryonic Kidney 293 cells) | |
| Substrate Description | cancer cell invasion | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (invasion) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cancer (invasion) | |
| Short Summary of Papers | copper-mediated Jagged1 proteolysis promote prostate cancer cell invasion | |
| Cleavage Information | NONE | |
| PMID | 22936788 |
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Start | End |
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34 | 1067 |
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1068 | 1093 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | HPCY*NSGT | 792 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | YRCE*CAPG | 807 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AVAE*VRVQ | 1054 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 22936788 | |||||
| PAPER | No_information | ADAM10 | 20819075 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 16944932 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |